Publications

• Research papers
• Reviews
• Books
• Topics

Research papers

23. Yu Mikame*, Haruki Toyama, Chikara Dohno, Takehiko Wada, Asako Yamayoshi*
    Development and functional evaluation of a psoralen-conjugated nucleoside mimic for triplex-forming oligonucleotides
    Commun Chem 8, 18 (2025). DOI: 10.1038/s42004-025-01416-2
24. Yu Mikame*, Nagisa Maekawa, Soichiro Kimura, Juki Nakao, Asako Yamayoshi*
    Modular Synthesis of Methyl-Substituted Novel Psoralen N-Hydroxysuccinimide Esters and Evaluation of DNA Photo-Crosslinking Properties of the Corresponding Triplex-Forming Oligonucleotide Conjugates, Synlett, 35, 1285-1290 1285-1290 (2024). DOI: 10.1055/a-2229-7441
    Selected as a “Front Cover”.
25. Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa-Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, Tsuyoshi Yamamoto*
    Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry, Nature Commun., 14, Article number: 7972 (2023). DOI: 10.1038/s41467-023-43714-0
26. Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano and Asako Yamayoshi*
    Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA, ChemMedChem, 18, e202300348. DOI:10.1002/cmdc.202300348
27. Shota Oyama, Mao Tomita, Moeka Hata, Yu Mikame, Tsuyoshi Yamamoto, Eishi Ashihara and Asako Yamayoshi*
    Exosome-hijacking drug delivery system with branched arginine linker effectively deliver antisense oligonucleotides into lung adeno-carcinoma cells, Chem. Pharm. Bull., 71(11), 819-823 (2023). DOI:10.1248/cpb.c23-00430
    Selected as a “Front Cover”.
    Selected as a “Highlighted paper selected by Editor-in-Chief” and “Featured Article”.
28. Yuri Sugimoto, Tadaharu Suga, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai and Shigeru Kawakami*
    Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives, Drug Delivery, 3, 2191891 (2023). DOI: 10.1080/10717544.2023.2191891
29. Juki Nakao, Yu Mikame, Honoka Eshima, Tsuyoshi Yamamoto, Chikara Dohno, Takehiko Wada, and Asako Yamayoshi*
    Unique Crosslinking Properties of Psoralen-conjugated Oligonucleotides developed by Novel Psoralen N-Hydroxysuccinimide Esters, ChemBioChem,24, e202200789 (2023). DOI: 10.1002/cbic.202200789
    Selected as a “Front Cover“.
    Selected as a “ChemBioTalents 2022/23″.
30. Yuri Sugimoto, Tadaharu Suga, Naoya Kato, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai and Shigeru Kawakami*
    Microfluidic Post-Insertion Method for the Efficient Preparation of PEGylated Liposomes Using High Functionality and Quality Lipids, Int. J. Nanomedicine, 17, 6675-6686, (2022). DOI: 10.2147/IJN.S390866
31. Yu Mikame, Yui Sakai, Ryo Tahara, Kinuka Doi, Tsuyoshi Yamamoto, Chikara Dohno, Takayuki Shibata and Asako Yamayoshi*
    Synthesis and Evaluation of Oligonucleotide-Containing 2’-O-{[(4,5’,8-trimethylpsoralen)-4’-ylmethoxy]ethylaminocarb-onyl}adenosine as Photo-crosslinkable Gene Targeting Tools, Chem. Pharm. Bull., Advance online publication (2022). DOI: 10.1248/cpb.c22-00333
32. Atsuhiro Kojima, Juki Nakao, Naohiko Shimada, Naoki Yoshida, Yota Abe, Yu Mikame, Tsuyoshi Yamamoto, Takehiko Wada, Atsushi Maruyama and Asako Yamayoshi*
    Selective Photo-Cross-Linking Detection of Methylated Cytosine in DNA Duplex Aided by a Cationic Comb-Type Copolymer, ACS Biomaterials Science & Engineering, 8, 1799-1805, (2022).  DOI: 10.1021/acsbiomaterials.2c00048
    Selected as a “Front Cover“.
33. Emi Soma , Asako Yamayoshi, Yuki Toda, Yuji Mishima, Shigekuni Hosogi and Eishi Ashihara*
    Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts, Cancers, 4, 566, (2022). DOI: 10.3390/cancers14030566
34. Fumito Wada, Tsuyoshi Yamamoto, Tadayuki Kobayashi, Keisuke Tachibana, Kosuke Ramon Ito, Mayumi Hamasaki, Yukina Kayaba, Chisato Terada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba*
    Drug Discovery and Development Scheme for Liver-targeting Bridged Nucleic Acid Antisense Oligonucleotides, Molecular Therapy – Nucleic Acids, 26, 957-969, (2021). DOI: 10.1016/j.omtn.2021.10.008
35. Chisato Terada, Fumito Wada, Mei Uchida, Yukari Yasutomi, Kaho Oh, Seiya Kawamoto, Yukina Kayaba, Asako Yamayoshi, Satoshi Obika, Mariko Harada-Shiba and Tsuyoshi Yamamoto*
    Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides, Nucleic Acid Therapeutics, 31, 404-416, (2021). DOI: 10.1089/nat.2021.0036
36. Asako Yamayoshi*, Hiroyuki Fukumoto, Rie Hayashi, Kyosuke Kishimoto, Akio Kobori, Yoshio Koyanagi, Jun A. Komano and Akira Murakami
    Development of 7SK snRNA mimics that inhibit HIV transcription, ChemMedChem, 16, 1-5 (2021). DOI: 10.1002/cmdc.202100422
37. Tsuyoshi Yamamoto*, Yahiro Mukai, Fumito Wada, Chisato Terada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba
    Highly Potent GalNAc-conjugated Tiny LNA anti-miRNA-122 Antisense Oligonucleotides, Pharmaceutics, 13, 817 (2021). DOI: 10.3390/pharmaceutics13060817
38. Takayuki Shibata*, Ryosuke Shimamura, Yuji Yamamoto, Hiroki Sakurai, Junya Fujita, Asako Yamayoshi, Toshimitsu Nemoto and Tsutomu Kabashima
    A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-specific Fluorescence Derivatization Reaction, Chem. Pharm. Bull., 69, 768-772,  (2021). DOI: 10.1248/cpb.c21-00221 
39. Asako Yamayoshi*, Shota Oyama, Yusuke Kishimoto, Ryo Konishi, Tsuyoshi Yamamoto, Akio Kobori, Hiroshi Harada, Eishi Ashihara, Hiroshi Sugiyama and Akira Murakami
    Development of Antibody-Oligonucleotide Complexes for targeting Exosomal microRNA, Pharmaceutics, 12(6), 545,  (2020). DOI: 10.3390/pharmaceutics12060545
40. Asako Yamayoshi*, Maiko Higuchi, Yui Sakai, Akio Kobori, Tsuyoshi Yamamoto, Takayuki Shibata and Akira Murakami
    Selective Cross-linking Behavior of Oligodeoxyribonucleotides containing 2’-O-[N-(4,5’,8-trimethylpsoralen-4′-ylmethylcarbamoyl)]adenosine to Mutant H-ras DNA, Nucleosides, Nucleotides & Nucleic Acids, 39: 119-130  (2020). DOI: 10.1080/15257770.2019.1677912
41. Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Fumito Wada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba
    Effect of Modular Conjugation Strategy for N-Acetylgalactosamine-targeted Antisense Oligonucleotides Nucleosides, Nucleosides, Nucleotides & Nucleic Acids, 39: 109-118  (2020). DOI: 10.1080/15257770.2019.1677911
42. Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Fumito Wada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba
    Effect of Modular Conjugation Strategy for N-Acetylgalactosamine-targeted Antisense Oligonucleotides Nucleosides, Nucleosides, Nucleotides & Nucleic Acids, 39: 109-118  (2020). DOI: 10.1080/15257770.2019.1677911
43. Takayuki Shibata, Hiroki Yoshimura, Asako Yamayoshi, Nobuaki Tsuda and Shpend Dragusha
    Hydrazide Derivatives of Luminol for Chemiluminescence-labelling of Macromolecules,Bull. Pharm. Soc. Japan, 67, 772-774 (2019). DOI: 10.1248/cpb.c19-00126
44. Akio Kobori, Taichiro Arai, Yuya Sakata, Takayuki Sugita, Asako Yamayoshi and Akira Murakami
    Photochromic DNA having Fluorescent Protein-inspired Nucleosides, Tetrahedron Letters, 59, 3690-3693 (2018). DOI: 10.1016/j.tetlet.2018.08.064
45. Sugai H., Nakase I., Sakamoto S., Nishio A., Inagaki M., Nishijima M., Yamayoshi A., Araki Y., Ishibashi S., Yokota T., Inoue Y. and Wada T.
    Peptide Ribonucleic Acid (PRNA)Arginine Hybrids. Effects of Arginine Residues Alternatingly Introduced to PRNA Backbone on Aggregation, Cellular Uptake, and Cytotoxicity, Chem. Lett, 47, 381-384 (2018). DOI: 10.1246/cl.171186

Click here before 2017：https://researchmap.jp/7000011330/published_papers

Reviews

1. Yu Mikame, Asako Yamayoshi
   Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids, Pharmaceutics, 15(10), 2515 (2023). DOI: 10.3390/pharmaceutics15102515
2. Chisato Terada, Seiya Kawamoto, Asako Yamayoshi and Tsuyoshi Yamamoto*
   Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules, Pharmaceutics, 14(12), 2647, (2022). DOI: 10.3390/pharmaceutics14122647
3. Juki Nakao, Tsuyoshi Yamamoto and Asako Yamayoshi*
   Therapeutic Application of Sequence-specific Binding Molecules for Novel Genome Editing tools, Drug Metabolism and Pharmacokinetics, 47, 42, 100427 (2022). DOI: 10.1016/j.dmpk.2021.100427
4. Juki Nakao, Tsuyoshi Yamamoto and Asako Yamayoshi*
   Therapeutic Application of Sequence-specific Binding Molecules for Novel Genome Editing tools, Drug Metabolism and Pharmacokinetics, 47, 42, 100427 (2022). DOI: 10.1016/j.dmpk.2021.100427
5. Shota Oyama, Tsuyoshi Yamamoto and Asako Yamayoshi*
   Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs, Cancers, 13, 3881 (2021). DOI: 10.3390/cancers13153881
6. Shintaro Fumoto*, Tsuyoshi Yamamoto, Kazuya Okami , Yuina Maemura , Chisato Terada , Asako Yamayoshi, Koyo Nishida
   Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs, Pharmaceutics, 13, 159 (2021). DOI: 10.3390/pharmaceutics13020159

Books

1. Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Asako Yamayoshi, Mariko Harada-Shiba and Satoshi Obika
   Synthesis of Monovalent N-Acetylgalactosamine Phosphoramidite for Liver-Targeting Oligonucleotides, Current Protocols in Nucleic Acid Chemistry, 78: e99  (2019). DOI: 10.1002/cpnc.99
2. Akio Kobori, AsakoYamayoshi, and Akira Murakami*
   Synthesis of oligonucleotides containing 4,5’,8-trimethylpsoralen at the 2′-O position and their cross-linking properties with RNAs, Current Protocols in Nucleic Acid Chemistry, 58: pp.1-15 (2014). DOI: 10.1002/0471142700.nc0515s58
3. Akira Murakami*, Asako Yamayoshi, Reiko Iwase, Jun-ichi Nishida, Tetsuji Yamaoka, and Norio Wake
   Photodynamic Antisense Regulation of Human Cervical Carcinoma Cell, Biomedical Polymers and Polymer Therapeutics,pp.389-396, Kluwer Academic/Plenum Publishers, U.S.A. (2001). DOI: 10.1016/s0928-0987(00)00204-9

Topics

• MEXT KAKENHI, Grant-in-Aid for Transformative Research Area (A), “Biophysical Chemistry for Material Symbiosis (Material Symbiosis)”.
  https://material-symbiosis.jp/en/