研究業績

• 原著論文
• 総説
• 著書
• その他

原著論文

1. Yu Mikame*, Haruki Toyama, Chikara Dohno, Takehiko Wada, Asako Yamayoshi*
   Development and functional evaluation of a psoralen-conjugated nucleoside mimic for triplex-forming oligonucleotides
   Commun Chem 8, 18 (2025). DOI: 10.1038/s42004-025-01416-2
2. Yu Mikame*, Nagisa Maekawa, Soichiro Kimura, Juki Nakao, Asako Yamayoshi*
   Modular Synthesis of Methyl-Substituted Novel Psoralen N-Hydroxysuccinimide Esters and Evaluation of DNA Photo-Crosslinking Properties of the Corresponding Triplex-Forming Oligonucleotide Conjugates, Synlett, 35, 1285-1290 1285-1290 (2024). DOI: 10.1055/a-2229-7441
   表紙に選出されました。
3. Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa-Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, Tsuyoshi Yamamoto*
   Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry, Nature Commun., 14, Article number: 7972 (2023). DOI: 10.1038/s41467-023-43714-0
4. Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano and Asako Yamayoshi*
   Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA, ChemMedChem, 18, e202300348. DOI:10.1002/cmdc.202300348
5. Shota Oyama, Mao Tomita, Moeka Hata, Yu Mikame, Tsuyoshi Yamamoto, Eishi Ashihara and Asako Yamayoshi*
   Exosome-hijacking drug delivery system with branched arginine linker effectively deliver antisense oligonucleotides into lung adeno-carcinoma cells, Chem. Pharm. Bull., 71(11), 819-823 (2023). DOI:10.1248/cpb.c23-00430
   表紙に選出されました。Highlighted paper selected by Editor-in-ChiefならびにFeatured Articleに選出されました。
6. Yuri Sugimoto, Tadaharu Suga, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai and Shigeru Kawakami*
   Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives, Drug Delivery, 3, 2191891 (2023). DOI: 10.1080/10717544.2023.2191891
7. Juki Nakao, Yu Mikame, Honoka Eshima, Tsuyoshi Yamamoto, Chikara Dohno, Takehiko Wada, and Asako Yamayoshi*
   Unique Crosslinking Properties of Psoralen-conjugated Oligonucleotides developed by Novel Psoralen N-Hydroxysuccinimide Esters, ChemBioChem,24, e202200789 (2023). DOI: 10.1002/cbic.202200789
   表紙に選出されました。ChemBioTalents2022/23に選出されました。
8. Yuri Sugimoto, Tadaharu Suga, Naoya Kato, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai and Shigeru Kawakami*
   Microfluidic Post-Insertion Method for the Efficient Preparation of PEGylated Liposomes Using High Functionality and Quality Lipids, Int. J. Nanomedicine, 17, 6675-6686, (2022). DOI: 10.2147/IJN.S390866
9. Yu Mikame, Yui Sakai, Ryo Tahara, Kinuka Doi, Tsuyoshi Yamamoto, Chikara Dohno, Takayuki Shibata and Asako Yamayoshi*
   Synthesis and Evaluation of Oligonucleotide-Containing 2’-O-{[(4,5’,8-trimethylpsoralen)-4’-ylmethoxy]ethylaminocarb-onyl}adenosine as Photo-crosslinkable Gene Targeting Tools, Chem. Pharm. Bull., Advance online publication (2022). DOI: 10.1248/cpb.c22-00333
10. Atsuhiro Kojima, Juki Nakao, Naohiko Shimada, Naoki Yoshida, Yota Abe, Yu Mikame, Tsuyoshi Yamamoto, Takehiko Wada, Atsushi Maruyama and Asako Yamayoshi*
    Selective Photo-Cross-Linking Detection of Methylated Cytosine in DNA Duplex Aided by a Cationic Comb-Type Copolymer, ACS Biomaterials Science & Engineering, 8, 1799-1805, (2022).  DOI: 10.1021/acsbiomaterials.2c00048
    表紙に選出されました。
11. Emi Soma , Asako Yamayoshi, Yuki Toda, Yuji Mishima, Shigekuni Hosogi and Eishi Ashihara*
    Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts, Cancers, 4, 566, (2022). DOI: 10.3390/cancers14030566
12. Fumito Wada, Tsuyoshi Yamamoto, Tadayuki Kobayashi, Keisuke Tachibana, Kosuke Ramon Ito, Mayumi Hamasaki, Yukina Kayaba, Chisato Terada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba*
    Drug Discovery and Development Scheme for Liver-targeting Bridged Nucleic Acid Antisense Oligonucleotides, Molecular Therapy – Nucleic Acids, 26, 957-969, (2021). DOI: 10.1016/j.omtn.2021.10.008
13. Chisato Terada, Fumito Wada, Mei Uchida, Yukari Yasutomi, Kaho Oh, Seiya Kawamoto, Yukina Kayaba, Asako Yamayoshi, Satoshi Obika, Mariko Harada-Shiba and Tsuyoshi Yamamoto*
    Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides, Nucleic Acid Therapeutics, 31, 404-416, (2021). DOI: 10.1089/nat.2021.0036
14. Asako Yamayoshi*, Hiroyuki Fukumoto, Rie Hayashi, Kyosuke Kishimoto, Akio Kobori, Yoshio Koyanagi, Jun A. Komano and Akira Murakami
    Development of 7SK snRNA mimics that inhibit HIV transcription, ChemMedChem, 16, 1-5 (2021). DOI: 10.1002/cmdc.202100422
15. Tsuyoshi Yamamoto*, Yahiro Mukai, Fumito Wada, Chisato Terada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba
    Highly Potent GalNAc-conjugated Tiny LNA anti-miRNA-122 Antisense Oligonucleotides, Pharmaceutics, 13, 817 (2021). DOI: 10.3390/pharmaceutics13060817
16. Takayuki Shibata*, Ryosuke Shimamura, Yuji Yamamoto, Hiroki Sakurai, Junya Fujita, Asako Yamayoshi, Toshimitsu Nemoto and Tsutomu Kabashima
    A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-specific Fluorescence Derivatization Reaction, Chem. Pharm. Bull., 69, 768-772,  (2021). DOI: 10.1248/cpb.c21-00221 
17. Asako Yamayoshi*, Shota Oyama, Yusuke Kishimoto, Ryo Konishi, Tsuyoshi Yamamoto, Akio Kobori, Hiroshi Harada, Eishi Ashihara, Hiroshi Sugiyama and Akira Murakami
    Development of Antibody-Oligonucleotide Complexes for targeting Exosomal microRNA, Pharmaceutics, 12(6), 545,  (2020). DOI: 10.3390/pharmaceutics12060545
18. Asako Yamayoshi*, Maiko Higuchi, Yui Sakai, Akio Kobori, Tsuyoshi Yamamoto, Takayuki Shibata and Akira Murakami
    Selective Cross-linking Behavior of Oligodeoxyribonucleotides containing 2’-O-[N-(4,5’,8-trimethylpsoralen-4′-ylmethylcarbamoyl)]adenosine to Mutant H-ras DNA, Nucleosides, Nucleotides & Nucleic Acids, 39: 119-130  (2020). DOI: 10.1080/15257770.2019.1677912
19. Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Fumito Wada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba
    Effect of Modular Conjugation Strategy for N-Acetylgalactosamine-targeted Antisense Oligonucleotides Nucleosides, Nucleosides, Nucleotides & Nucleic Acids, 39: 109-118  (2020). DOI: 10.1080/15257770.2019.1677911
20. Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Fumito Wada, Asako Yamayoshi, Satoshi Obika and Mariko Harada-Shiba
    Effect of Modular Conjugation Strategy for N-Acetylgalactosamine-targeted Antisense Oligonucleotides Nucleosides, Nucleosides, Nucleotides & Nucleic Acids, 39: 109-118  (2020). DOI: 10.1080/15257770.2019.1677911
21. Takayuki Shibata, Hiroki Yoshimura, Asako Yamayoshi, Nobuaki Tsuda and Shpend Dragusha
    Hydrazide Derivatives of Luminol for Chemiluminescence-labelling of Macromolecules,Bull. Pharm. Soc. Japan, 67, 772-774 (2019). DOI: 10.1248/cpb.c19-00126
22. Akio Kobori, Taichiro Arai, Yuya Sakata, Takayuki Sugita, Asako Yamayoshi and Akira Murakami
    Photochromic DNA having Fluorescent Protein-inspired Nucleosides, Tetrahedron Letters, 59, 3690-3693 (2018). DOI: 10.1016/j.tetlet.2018.08.064
23. Sugai H., Nakase I., Sakamoto S., Nishio A., Inagaki M., Nishijima M., Yamayoshi A., Araki Y., Ishibashi S., Yokota T., Inoue Y. and Wada T.
    Peptide Ribonucleic Acid (PRNA)Arginine Hybrids. Effects of Arginine Residues Alternatingly Introduced to PRNA Backbone on Aggregation, Cellular Uptake, and Cytotoxicity, Chem. Lett, 47, 381-384 (2018). DOI: 10.1246/cl.171186

2017年以前はこちら：https://researchmap.jp/7000011330/published_papers

総説

1. 井上佳奈、秦萌花、山吉麻子
   核酸医薬品の進展と免疫応答回避のための技術的アプローチ, ファルマシア, 61 巻, 3 号, 181-185 (2025)
2. 秦萌花、山吉麻子
   細胞外小胞を用いた核酸医薬送達, 週刊『医学のあゆみ』特集号第291巻9号「細胞外小胞・エクソソームの医療応用の未来」,
3. Yu Mikame, Asako Yamayoshi
   Recent Advancements in Development and Therapeutic Applications of Genome-Targeting Triplex-Forming Oligonucleotides and Peptide Nucleic Acids, Pharmaceutics, 15(10), 2515 (2023). DOI: 10.3390/pharmaceutics15102515
4. 中尾樹希、三瓶悠、山吉麻子*
   ゲノムDNAを標的とした光駆動核酸の開発, 光アライアンス10月号 多様化するバイオテクノロジーと光技術, 30-34 (2023)
5. 三瓶悠、山本剛史、山吉麻子*
   核酸医薬とゲノム編集技術, 光CLINICAL NEUROSCIENCE, 41, 05月号 核酸医薬と神経疾患 (2023)
6. Chisato Terada, Seiya Kawamoto, Asako Yamayoshi and Tsuyoshi Yamamoto*
   Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules, Pharmaceutics, 14(12), 2647, (2022). DOI: 10.3390/pharmaceutics14122647
7. Juki Nakao, Tsuyoshi Yamamoto and Asako Yamayoshi*
   Therapeutic Application of Sequence-specific Binding Molecules for Novel Genome Editing tools, Drug Metabolism and Pharmacokinetics, 47, 42, 100427 (2022). DOI: 10.1016/j.dmpk.2021.100427
8. Juki Nakao, Tsuyoshi Yamamoto and Asako Yamayoshi*
   Therapeutic Application of Sequence-specific Binding Molecules for Novel Genome Editing tools, Drug Metabolism and Pharmacokinetics, 47, 42, 100427 (2022). DOI: 10.1016/j.dmpk.2021.100427
9. Shota Oyama, Tsuyoshi Yamamoto and Asako Yamayoshi*
   Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs, Cancers, 13, 3881 (2021). DOI: 10.3390/cancers13153881
10. Shintaro Fumoto*, Tsuyoshi Yamamoto, Kazuya Okami , Yuina Maemura , Chisato Terada , Asako Yamayoshi, Koyo Nishida
    Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs, Pharmaceutics, 13, 159 (2021). DOI: 10.3390/pharmaceutics13020159
11. 中尾樹希, 山本剛史, 山吉麻子*
    ゲノム編集技術と核酸医薬, 実験医学増刊「核酸医薬　本領を発揮する創薬モダリティ」,39, 67-73 (2021).
12. 山吉麻子*
    物質共生の観点からDDSを考える　〜「共生」と「非共生」の狭間で〜, Drug Delivery System, 37, 99-99 (2022).
13. 山本剛史*、山吉麻子*
    核酸医薬の物性制御による有効性・安全性へのアプローチ 〜核酸医薬との物質共生に向けて〜, Drug Delivery System, 37, 131-141 (2022).
14. 山吉麻子*
    エクソソーム随伴導入型薬物送達システムの開発, YAKUGAKU ZASSHI, 140, 625-631 (2020)
15. 山吉麻子*
    新しい創薬モダリティ：核酸医薬, 人工臓器, 48, 3, 195-198 (2019).
16. 山吉麻子*
    仕事と私事　お母さんとお父さんの狭間で, 高分子学会誌, 11, 612 (2019).
17. 山吉麻子*
    エクソソームに随伴し標的細胞へ侵入する抗体結合型核酸ドラッグ, Drug Delivery System, 32, 54-55 (2018).
18. 山吉麻子*
    細胞外微粒子を追跡する遺伝子制御分子　～非コードRNA を操って生命現象を操る～, 生命科学研究レター, 57, 4-9 (2018).
19. 山吉麻子*
    長崎の中心で核酸化学を叫ぶ, 日本核酸化学会誌, 2, 31-34 (2018).

2017年以前はこちら：https://researchmap.jp/7000011330/misc

著書

1. 大山将大, 相馬瑛美, 芦原英司, 山吉麻子*
   第3章　生体反応を利用したDDS, 3節　エクソソームの特性に基づく DDS 技術の開発と展望, 医薬品におけるDDS技術開発と製剤への応用（株式会社 情報機構）pp.161-171 (2021)
2. 山本剛史, 山吉麻子*
   miRNA (microRNA), 核酸化学ハンドブック, 講談社サイエンティフィック（日本核酸化学会・監　杉本直己・編）(2020)
3. Tsuyoshi Yamamoto*, Chisato Terada, Koki Kashiwada, Asako Yamayoshi, Mariko Harada-Shiba and Satoshi Obika
   Synthesis of Monovalent N-Acetylgalactosamine Phosphoramidite for Liver-Targeting Oligonucleotides, Current Protocols in Nucleic Acid Chemistry, 78: e99  (2019). DOI: 10.1002/cpnc.99
4. 山吉麻子*
   核酸医薬の各作用機序と概要 miRNA標的, 医薬品開発における中分子領域（核酸医薬・ペプチド医薬）の開発戦略（株式会社情報機構）pp.26-32 (2019)
5. 山吉麻子*
   siRNA、miRNA-mimic、anti-miR核酸の設計指針, 中分子医薬開発に資するペプチド・核酸・糖鎖の合成・高機能化技術（シーエムシー出版）pp.189-198 (2018).

2017年以前はこちら：https://researchmap.jp/7000011330/books_etc

その他

• 文部科学省科学研究費補助金・学術変革領域（Ａ）「マテリアル・シンバイオシスのための生命物理化学（略称：物質共生）」を推進しています。
  https://material-symbiosis.jp